Description

3-Chloro-2,6-Difluorobenzyl Alcohol is a versatile fluorinated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine atoms on the aromatic ring, which allows for selective functionalization and modulation of electronic properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro substituents enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and electron-transport/hole-blocking materials in organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or chain modifier for introducing fluorine and chlorine functionalities into specialty polymers, improving chemical resistance and thermal stability.
• Cross-Coupling Reactions: The benzyl alcohol group can be transformed into halides or other leaving groups, making it a valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Ligand & Catalyst Development: Utilized in the synthesis of novel chiral or fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Chloro-2,6-Difluorobenzyl Alcohol
CAS No.	252004-35-6
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	(3-Chloro-2,6-difluorophenyl)methanol; 2,6-Difluoro-3-chlorobenzyl Alcohol; 3-Chloro-2,6-difluorobenzenemethanol; Benzyl alcohol, 3-chloro-2,6-difluoro-; 252004-35-6; 3-Chloro-2,6-difluoro-benzenemethanol
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,6-Difluorobenzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory requirements for R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent oxidation or hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.