Description

Dynamin Inhibitory Peptide, Myristoylated is a cell-permeable, synthetic peptide inhibitor designed to specifically target and block dynamin GTPase activity. This compound is a critical research tool for studying clathrin-mediated endocytosis, vesicle trafficking, and other dynamin-dependent cellular processes. It is primarily utilized by researchers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on neurobiology, virology, and receptor signaling pathways.

Application

• Mechanistic Studies of Endocytosis: Used to inhibit clathrin-mediated and caveolae-dependent endocytosis in cell culture models.
• Neurobiological Research: Investigates the role of dynamin in synaptic vesicle recycling and neurotransmitter release.
• Virology and Pathogen Entry: Employed to study viral entry mechanisms that rely on host cell endocytic pathways.
• Receptor Trafficking and Signaling: Helps elucidate the internalization and downstream signaling of G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs).
• Drug Discovery Screening: Serves as a reference inhibitor in high-throughput assays targeting endocytic machinery.
• Cell Biology Tool: Applied in fluorescence microscopy and live-cell imaging experiments to visualize the real-time inhibition of vesicle formation.

Basic Information

Product Name	Dynamin Inhibitory Peptide, Myristoylated
CAS No.	251634-22-7
Molecular Formula	C95H155N27O26S
Molecular Weight	2151.5 g/mol
Synonyms	Myr-Dynamin Inhibitory Peptide; Myristoylated Dynamin Inhibitory Peptide; Dynasore Peptide Inhibitor; Myr-4 peptide; Dynamin I Inhibitory Peptide; QPSRARTDLPTLPTL; H2N-QPSRARTDLPTLPTL-CONH2 (Myristoylated); N-Myristoyl-Gln-Pro-Ser-Arg-Ala-Arg-Thr-Asp-Leu-Pro-Thr-Leu-Pro-Thr-Leu-NH2
EINECS	Contact for details

Quality Control

Our Dynamin Inhibitory Peptide, Myristoylated is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder under an inert atmosphere. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥95%
Peptide Content	≥80%
Solvent Residues	Meets ICH guidelines
Water Content (KF)	≤5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.