Description

Fmoc-D-Dap-Oh Hcl CAS NO 251317-00-7 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of D-2,3-diaminopropionic acid into peptide chains, enabling the creation of complex and novel peptide structures. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of custom peptides, particularly those requiring D-configuration amino acids.
• Pharmaceutical Research: Used in the development of peptide-based drug candidates, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic and research applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: A fundamental reagent for studying peptide structure-activity relationships, enzyme substrates, and receptor ligands.
• Production of Specialty Peptides: Enables the commercial-scale synthesis of peptides containing the non-proteinogenic amino acid D-2,3-diaminopropionic acid.

Basic Information

Product Name	Fmoc-D-Dap-Oh Hcl
CAS No.	251317-00-7
Molecular Formula	C₁₉H₁₉N₂O₅ • HCl
Molecular Weight	394.82 g/mol (Free base: 355.37 g/mol)
Synonyms	Fmoc-D-2,3-diaminopropionic acid hydrochloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2,3-diaminopropanoic acid hydrochloride; Fmoc-D-Dap-OH•HCl; Fmoc-D-Dap(HCl)-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid hydrochloride; N-α-Fmoc-D-2,3-diaminopropionic acid HCl; D-Fmoc-Dap-OH HCl salt
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dap-Oh Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.