Description

Fmoc-Lys(Tnm)-Oh CAS NO 251316-95-7 is a specialized, orthogonally protected derivative of the amino acid lysine, featuring the 9-fluorenylmethoxycarbonyl (Fmoc) group on the α-amine and the 4-methyltrityl (Trt) or trityl (Trt) group on the ε-amine. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the precise and sequential assembly of complex peptides. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in the discovery and production of therapeutic peptides, peptide-based diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides, allowing for selective deprotection of the α-amine during chain elongation.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals targeting metabolic disorders, oncology, and infectious diseases.
• Peptide Library Construction: Essential for creating combinatorial peptide libraries for high-throughput screening in drug discovery and epitope mapping.
• Bioconjugation and Labeling: Serves as a precursor for introducing lysine residues with a selectively addressable side-chain for attaching fluorescent probes, biotin, or other functional tags.
• Antibody-Drug Conjugate (ADC) Research: Provides a controlled point of attachment for linker-payload systems via the ε-amine after selective deprotection.
• Biochemical Research: Employed in studying protein-protein interactions, enzyme kinetics, and signal transduction pathways using synthetic peptide substrates or inhibitors.

Basic Information

Product Name	Fmoc-Lys(Tnm)-Oh
CAS No.	251316-95-7
Molecular Formula	C36H34N2O5
Molecular Weight	574.67 g/mol
Synonyms	Nα-Fmoc-Nε-trityl-L-lysine; Fmoc-Lys(Trt)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-(triphenylmethyl)-L-lysine; Fmoc-Nε-Trt-L-lysine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(tritylamino)hexanoic acid; Fmoc-Lys(Mtt)-OH (common alternative); Fmoc-L-Lys(Trt)-OH; Nα-Fmoc-Nε-Mtt-L-lysine
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Tnm)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for peptide synthesis. Key parameters including chiral purity, chemical purity, and residual solvent content are verified. Certificates of Analysis (COA) detailing HPLC, NMR, and MS data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.