Description

Fmoc-Trp-Pro-Oh CAS NO 251316-94-6 is a protected dipeptide building block, specifically the Fmoc-derivative of the Tryptophan-Proline sequence. This compound is essential for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, offering high coupling efficiency and minimal racemization. It is a critical raw material for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel therapeutic agents and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the sequential assembly of custom peptides in research and GMP production.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) for potential drug candidates targeting various diseases.
• Bioconjugation and Probe Development: Serves as a key component for creating fluorescently labeled or otherwise tagged peptides for diagnostic and imaging applications.
• Peptidomimetic Research: Integral for designing and synthesizing peptide analogs with enhanced stability, bioavailability, or biological activity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: Used to study protein-protein interactions, enzyme substrates, and receptor ligands.

Basic Information

Product Name	Fmoc-Trp-Pro-Oh
CAS No.	251316-94-6
Molecular Formula	C₃₁H₂₉N₃O₅
Molecular Weight	523.58 g/mol
Synonyms	Fmoc-Tryptophanyl-Proline; Fmoc-Trp-Pro; Fmoc-L-Tryptophanyl-L-Proline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tryptophyl-L-proline; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-indol-3-yl)-N-((S)-pyrrolidine-2-carbonyl)propanamide; Fmoc-L-Trp-L-Pro-OH; Fmoc-Trp(Boc)-Pro-OH (if side-chain protected); Fmoc-Tryptophan-Proline
EINECS	Contact for details

Quality Control

Our Fmoc-Trp-Pro-Oh is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance in GMP and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.