Description

Fmoc-Nle-Nle-Oh CAS NO 251316-91-3 is a protected dipeptide building block featuring two norleucine residues, widely used in solid-phase peptide synthesis (SPPS). Its primary value lies in providing a hydrophobic, non-natural amino acid sequence that enhances peptide stability and modulates biological activity. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected dipeptide fragment for the efficient, sequential construction of longer peptide chains.
• Pharmaceutical Research: Used in the discovery and development of novel therapeutic peptides targeting various diseases.
• Peptidomimetic Design: Incorporation of norleucine residues aids in creating metabolically stable analogs of natural peptides.
• Bioconjugation & Probe Synthesis: Serves as a building block for creating labeled peptides used in diagnostic assays and imaging studies.
• Academic & Industrial R&D: Fundamental reagent for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).
• Custom Peptide Service Providers: A critical raw material for companies offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Nle-Nle-Oh
CAS No.	251316-91-3
Molecular Formula	C₃₁H₄₀N₂O₆
Molecular Weight	536.66 g/mol
Synonyms	Fmoc-Norleucyl-norleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucyl-L-norleucine; Fmoc-L-Nle-L-Nle-OH; Fmoc-Nle-Nle; N-α-Fmoc-Norleucyl-norleucine; (S)-2-(((S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methylhexyl)amino)-6-methylheptanoic acid; Fmoc-Nle-Nle-OH; Fmoc-Nle-Nle-Acid
EINECS	Contact for details

Quality Control

Our Fmoc-Nle-Nle-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical applications, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.