Description

Urotensin II (Human) is a potent cyclic neuropeptide and the endogenous ligand for the G-protein-coupled receptor UT. This compound is of significant interest in cardiovascular and metabolic research due to its powerful vasoconstrictive properties, which are among the most potent in mammals. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on studying hypertension, heart failure, renal function, and related metabolic disorders.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating the urotensin system's role in cardiovascular physiology and pathology.
• Drug Discovery & Development: Serves as a critical tool for screening and validating novel UT receptor antagonists or agonists for therapeutic applications.
• Biochemical Assays: Employed in receptor binding studies, functional cellular assays (e.g., calcium flux), and signal transduction pathway analysis.
• Academic & Clinical Research: Facilitates fundamental research into its effects on vascular tone, cardiac contractility, and its potential role in diseases like atherosclerosis and diabetes.
• In Vitro Diagnostics (IVD) Development: Can be used as a calibrator or control in the development of immunoassays designed to measure urotensin II levels in biological samples.

Basic Information

Product Name	Urotensin II (Human)
CAS No.	251293-28-4
Molecular Formula	C106H146N26O28S2
Molecular Weight	1388.6 g/mol
Synonyms	Human Urotensin II; hUII; U-II; Urotensin-2; UTS2; UII (Human); Cyclo[L-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val]; H-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (disulfide bridge: Cys2-Cys7)
EINECS	Contact for details

Quality Control

Our Urotensin II (Human) is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including mass spectrometry (MS) for identity confirmation and high-performance liquid chromatography (HPLC) for purity assessment. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Endotoxin Level (LAL)	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.