Description

Pyrimidine, 4-Fluoro-2-[(Fluoromethyl)Thio]- (9Ci) is a fluorinated and sulfur-containing heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique substitution pattern enables precise modulation of biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated pyrimidine scaffolds into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of fluorinated pyrimidine derivatives.
• Chemical Biology Probe: Employed in medicinal chemistry to study structure-activity relationships (SAR) and enzyme inhibition mechanisms.
• Material Science Precursor: Potential use in the synthesis of functionalized ligands for catalysis or advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A valuable substrate for fine chemical manufacturers offering bespoke synthesis services to global clients.

Basic Information

Product Name	Pyrimidine, 4-Fluoro-2-[(Fluoromethyl)Thio]- (9Ci)
CAS No.	250690-60-9
Molecular Formula	C5H4F2N2S
Molecular Weight	162.16 g/mol
Synonyms	4-Fluoro-2-[(fluoromethyl)thio]pyrimidine; 2-[(Fluoromethyl)thio]-4-fluoropyrimidine; 4-Fluoro-2-(fluoromethylsulfanyl)pyrimidine; 250690-60-9; SCHEMBL21842227; AKOS040759623; F2198-6965; ZINC000257409315
EINECS	Contact for details

Quality Control

Our Pyrimidine, 4-Fluoro-2-[(Fluoromethyl)Thio]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.