Description

Cyclo(L-Arginylglycyl-L-α-Aspartyl-D-Phenylalanyl-L-Lysyl), 5,5'-[n-[2-[4,7,10-Tris(Carboxymethyl)-1,4,7,10-Tetraazacyclododec-1-Yl]Acetyl]-L-Glutamoyl]Bis- is a sophisticated, high-purity synthetic peptide derivative designed for advanced research and development applications. This compound is engineered for its specific chelating and targeting properties, making it a critical component in the development of novel diagnostic and therapeutic agents. It is primarily utilized by pharmaceutical researchers and biotechnology companies focused on molecular imaging, targeted drug delivery systems, and radiopharmaceuticals.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for labeling peptides with diagnostic or therapeutic radioisotopes (e.g., Gallium-68, Lutetium-177).
• Molecular Imaging Probes: Used in the synthesis of targeted contrast agents for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).
• Targeted Drug Delivery Conjugates: Serves as a linker to attach cytotoxic drugs or other therapeutic payloads to specific targeting peptides or antibodies.
• Research Chemical: Employed in biochemical and pharmacological studies investigating receptor-ligand interactions and cell signaling pathways.
• Diagnostic Kit Development: A key intermediate in the manufacture of in-vitro diagnostic (IVD) kits for research and clinical use.

Basic Information

Product Name	Cyclo(L-Arginylglycyl-L-α-Aspartyl-D-Phenylalanyl-L-Lysyl), 5,5'-[n-[2-[4,7,10-Tris(Carboxymethyl)-1,4,7,10-Tetraazacyclododec-1-Yl]Acetyl]-L-Glutamoyl]Bis-
CAS No.	250612-06-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DOTA-Glu-Cyc(RGDfK)₂; DOTA-E[c(RGDfK)₂]; Cyclo(Arg-Gly-Asp-D-Phe-Lys) conjugated to DOTA via glutamic acid; DOTA-Glu-cyclo(RGDfK)₂; c(RGDfK)₂-DOTA; Bifunctional Chelator RGD Conjugate; DOTA-E-c(RGDfK)₂; DOTA-Glu-[cyclo(RGDfK)]₂
EINECS	Contact for details

Quality Control

Our Cyclo(L-Arginylglycyl-L-α-Aspartyl-D-Phenylalanyl-L-Lysyl), 5,5'-[n-[2-[4,7,10-Tris(Carboxymethyl)-1,4,7,10-Tetraazacyclododec-1-Yl]Acetyl]-L-Glutamoyl]Bis- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pre-clinical development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.