Description

Boc-Pen(Npys)-Oh is a specialized, protected amino acid derivative used as a key building block in peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over disulfide bond formation and thiol-specific conjugation in complex biomolecules. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of therapeutic peptides, antibody-drug conjugates (ADCs), and diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected cysteine analog for the controlled introduction of disulfide bridges in peptide chains.
• Antibody-Drug Conjugate (ADC) Development: For site-specific conjugation of cytotoxic payloads to antibodies via thiol-reactive chemistry.
• Peptide Drug Discovery: Enables the synthesis of structurally defined peptide libraries for screening and optimization.
• Bioconjugation & Labeling: Used to attach fluorescent dyes, biotin, or other functional groups to proteins and peptides in a controlled manner.
• Research Reagent: Serves as a critical intermediate in academic and industrial research focused on protein engineering and chemical biology.

Basic Information

Product Name	Boc-Pen(Npys)-Oh
CAS No.	250375-03-2
Molecular Formula	C₁₇H₂₂N₂O₆S₂
Molecular Weight	414.50 g/mol
Synonyms	Boc-Penicillamine(Npys)-OH; N-(tert-Butoxycarbonyl)-3-[(2-nitrophenyl)dithio]-D-valine; Boc-D-Pen(Npys)-OH; Boc-S-(2-Nitrophenylsulfenyl)-D-penicillamine; tert-Butyloxycarbonyl-S-(2-nitrophenylsulfenyl)-D-penicillamine; (R)-2-((tert-Butoxycarbonyl)amino)-3-((2-nitrophenyl)disulfaneyl)-3-methylbutanoic acid; Boc-D-Penicillamine(Npys)
EINECS	Contact for details

Quality Control

Our Boc-Pen(Npys)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.