Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-2-(methylthio)- is a sophisticated nucleoside analog derivative with significant potential in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for novel antiviral and anticancer therapeutics, offering a high degree of stereochemical purity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries focused on nucleoside-based drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Investigated for its potential as a precursor or active moiety in the development of new antiviral agents.
• Oncology Research: Used in the discovery and development of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Tool Compound: Employed in enzymatic studies and as a probe to understand cellular nucleoside metabolism and related pathways.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and GMP manufacturing campaigns for advanced pharmaceutical candidates.
• Academic Research: Supports fundamental research in medicinal chemistry, chemical biology, and drug design within university and institutional laboratories.

Basic Information

Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-2-(methylthio)-
CAS No.	249503-34-2
Molecular Formula	C13H18N4O5S
Molecular Weight	342.37 g/mol
Synonyms	7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-2-(methylthio)-4H,5H-pyrrolo[3,2-d]pyrimidin-4-one; 2-(Methylthio)-7-((2S,3S,4R,5R)-3,4,5-trihydroxypentahydropyrrol-2-yl)-4H,5H-pyrrolo[3,2-d]pyrimidin-4-one; 7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-2-(methylthio)-4H-pyrrolo[3,2-d]pyrimidin-4-one; A thionucleoside analog; CAS 249503-34-2.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. We employ advanced analytical techniques including HPLC, NMR, and MS to verify identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing lot-specific results are available upon request. Our quality systems support development from milligram to kilogram scale, with a focus on consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.