Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5S)-5-(fluoromethyl)-3,4-dihydroxy-2-pyrrolidinyl]-1,5-dihydro- is a high-purity, fluorinated nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound matters as a sophisticated chiral intermediate, enabling the synthesis of novel therapeutic agents targeting viral and oncological pathways. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of next-generation antiviral and anticancer drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel nucleoside-based antiviral drugs.
• Antiviral Drug Discovery: Serves as a critical building block in the synthesis of potential therapeutics targeting DNA and RNA viruses.
• Oncology Research: Used in the development of experimental chemotherapeutic agents that interfere with cellular nucleotide metabolism.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate substrate specificity and inhibition mechanisms of nucleoside-processing enzymes.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of more complex, target-specific molecules for client-driven projects.

Basic Information

Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5S)-5-(fluoromethyl)-3,4-dihydroxy-2-pyrrolidinyl]-1,5-dihydro-
CAS No.	249503-28-4
Molecular Formula	C12H15FN4O3
Molecular Weight	282.27 g/mol
Synonyms	7-[(2S,3S,4R,5S)-5-(Fluoromethyl)-3,4-dihydroxy-2-pyrrolidinyl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; (2S,3S,4R,5S)-2-(4-Oxo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(fluoromethyl)pyrrolidine-3,4-diol; Fluoromethyl-dihydroxypyrrolidinyl pyrrolopyrimidinone; Nucleoside analog intermediate; Fluorinated pyrrolopyrimidine derivative
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research and development. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.