Description

2-Trifluoromethyl-4-Fluorobenzyl Chloride is a high-value, multi-functional aromatic building block characterized by its reactive benzyl chloride group and electron-withdrawing fluorine substituents. This compound is essential for introducing the 2-trifluoromethyl-4-fluorobenzyl moiety into complex molecular architectures, enabling the fine-tuning of physicochemical properties. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the trifluoromethyl and fluorine groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated benzyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: A versatile substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new fluorinated compounds and reaction methodologies.

Basic Information

Product Name	2-Trifluoromethyl-4-Fluorobenzyl Chloride
CAS No.	248262-29-5
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	4-Fluoro-2-(trifluoromethyl)benzyl Chloride; 1-(Chloromethyl)-4-fluoro-2-(trifluoromethyl)benzene; α-Chloro-4-fluoro-α,α,α-trifluoro-o-xylene; (4-Fluoro-2-trifluoromethylphenyl)methyl Chloride; 2-Trifluoromethyl-4-fluorobenzylchloride; 4-Fluoro-α,α,α-trifluoro-o-tolyl Chloride; 2-(Trifluoromethyl)-4-fluorobenzyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Trifluoromethyl-4-Fluorobenzyl Chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.