Description

2,4,6-Trifluorobenzyl Chloride is a versatile and highly reactive organofluorine building block, essential for introducing the trifluorobenzyl moiety into complex molecular architectures. Its value lies in enabling precise structural modifications that enhance the physicochemical properties of target compounds, such as metabolic stability and lipophilicity. This intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for high-performance displays and optical devices.
• Functional Polymer Building Block: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, or surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, nucleophilic substitutions, and as a starting material for other benzyl halide derivatives in fine chemical production.
• Material Science Research: Utilized in the development of novel organic electronic materials, such as semiconductors and light-emitting compounds.

Basic Information

Product Name	2,4,6-Trifluorobenzyl Chloride
CAS No.	247564-62-1
Molecular Formula	C7H4ClF3
Molecular Weight	192.56 g/mol
Synonyms	α-Chloro-2,4,6-trifluorotoluene; (2,4,6-Trifluorophenyl)methyl chloride; 2,4,6-Trifluorobenzylchloride; 1-(Chloromethyl)-2,4,6-trifluorobenzene; Benzene, 1-(chloromethyl)-2,4,6-trifluoro-; 2,4,6-Trifluoro-α-chlorotoluene
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluorobenzyl Chloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.