Description

Fmoc-β-Homoaspartic Acid CAS NO 247217-28-3 is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide chain elongation and the introduction of modified aspartic acid analogs. It serves as an essential building block for the pharmaceutical, biotechnology, and life sciences industries, enabling the development of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled incorporation of β-homoaspartic acid residues into peptide sequences using Fmoc-chemistry protocols.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including enzyme inhibitors, receptor agonists/antagonists, and diagnostic agents.
• Peptidomimetics Design: Facilitates the creation of modified peptides with enhanced metabolic stability, bioavailability, or altered biological activity by introducing a homologated aspartic acid side chain.
• Bioconjugation and Labeling: Serves as a precursor for synthesizing custom amino acids for site-specific protein and antibody labeling or immobilization.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Academic & Institutional Research: A fundamental reagent for studies in organic chemistry, medicinal chemistry, and chemical biology focused on peptide structure-activity relationships.

Basic Information

Product Name	Fmoc-β-Homoaspartic Acid
CAS No.	247217-28-3
Molecular Formula	C₂₀H₁₉NO₆
Molecular Weight	369.37 g/mol
Synonyms	Fmoc-β-Homo-Asp-OH; N-(9-Fluorenylmethoxycarbonyl)-β-homo-L-aspartic acid; Fmoc-L-β-homoaspartic acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid; Fmoc-Asp(β-CH₂)-OH; Fmoc-β-h-Asp-OH; Nα-Fmoc-β-homoaspartic acid; Fmoc-β-homo-Asp
EINECS	Contact for details

Quality Control

Our Fmoc-β-Homoaspartic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, MS). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.