Description

4-(2,2,2-Trifluoro-1-Hydroxyethyl)Phenol is a high-value fluorinated phenolic intermediate with a unique trifluoroethanol side chain. This compound is critical for introducing fluorine atoms into target molecules, thereby enhancing their metabolic stability, lipophilicity, and binding affinity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in display technologies.
• Advanced Polymer Chemistry: Incorporation into specialty polymers to impart unique surface properties, chemical resistance, and thermal stability.
• Organic Synthesis & Catalysis: Valuable scaffold in academic and industrial research for exploring new fluorination methodologies and asymmetric synthesis.
• Material Science Research: Used in the development of novel coatings and additives with specific performance characteristics.

Basic Information

Product Name	4-(2,2,2-Trifluoro-1-Hydroxyethyl)Phenol
CAS No.	246245-20-5
Molecular Formula	C8H7F3O2
Molecular Weight	192.14 g/mol
Synonyms	4-(2,2,2-Trifluoro-1-hydroxyethyl)phenol; 1-(4-Hydroxyphenyl)-2,2,2-trifluoroethanol; α-(Trifluoromethyl)-4-hydroxybenzyl alcohol; 2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanol; 4-Hydroxy-α-(trifluoromethyl)benzyl Alcohol; p-(2,2,2-Trifluoro-1-hydroxyethyl)phenol; CAS 246245-20-5
EINECS	Contact for details

Quality Control

Our 4-(2,2,2-Trifluoro-1-Hydroxyethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as oxidizing agents and bases. The compound is sensitive to light and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.