Description

Ethyl 4-Chloro-5-Methyl-7-Phenyl-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyrimidine class of heterocyclic compounds. This compound is a critical building block in the synthesis of targeted small-molecule therapeutics, particularly kinase inhibitors, due to its complex and functionalized core structure. It is essential for research and development chemists in the pharmaceutical and biotechnology sectors working on novel drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of protein kinase inhibitors for oncology and inflammatory diseases.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthetic routes to construct the core scaffold of final drug molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Can be utilized in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for custom synthesis and scale-up projects.
• Academic Research: Employed in university and institutional labs for the study of heterocyclic chemistry and novel synthetic methodologies.

Basic Information

Product Name	Ethyl 4-Chloro-5-Methyl-7-Phenyl-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	245728-43-2
Molecular Formula	C₁₆H₁₄ClN₃O₂
Molecular Weight	315.75 g/mol
Synonyms	4-Chloro-5-methyl-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; Ethyl 4-chloro-5-methyl-7-phenyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate; 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylic acid, 4-chloro-5-methyl-7-phenyl-, ethyl ester; Pyrrolo[2,3-d]pyrimidine derivative; CAS 245728-43-2
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-5-Methyl-7-Phenyl-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and current industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.