Description

(Phe1,Ser2,Tyr6)-Par-1 (1-6) Amide (Human) is a synthetic peptide fragment of the human parathyroid hormone-related protein (PTHrP). This compound is a critical research tool for studying bone metabolism, calcium regulation, and the pathophysiology of hypercalcemia of malignancy. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on endocrinology and oncology. The peptide's specific sequence allows for targeted investigation of receptor binding and signal transduction pathways.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of PTH/PTHrP receptor (PTH1R) signaling and bone biology.
• Drug Discovery & Development: Serves as a lead compound or pharmacological tool for screening and developing novel therapeutics targeting calcium disorders and bone diseases.
• Assay Development: Employed in the calibration and validation of immunoassays (ELISA, RIA) and cell-based bioassays designed to measure PTHrP activity or related biomarkers.
• Academic Studies: Facilitates fundamental research into the role of PTHrP fragments in cancer progression, skeletal development, and cardiovascular functions.
• Peptide Chemistry Reference: Acts as a characterized intermediate or standard for synthetic peptide chemistry and analytical method development.

Basic Information

Item	Details
Product Name	(Phe1,Ser2,Tyr6)-Par-1 (1-6) Amide (Human)
CAS No.	245329-02-6
Molecular Formula	C38H51N9O9
Molecular Weight	777.87 g/mol
Synonyms	PTHrP (1-6) amide (human); Parathyroid Hormone-Related Protein (1-6) amide fragment; [Phe1,Ser2,Tyr6]-hPTHrP-(1-6)-NH2; hPTHrP(1-6)NH2 analog; PTHrP 1-6 peptide amide; PTHrP (1-6) (human); ALPHE-SER-TYR-LEU-ARG-HIS-TYRAMIDE (sequence-based); PTHrP N-terminal fragment
EINECS	Contact for details

Quality Control

Every batch of (Phe1,Ser2,Tyr6)-Par-1 (1-6) Amide (Human) is manufactured under strict quality management systems. The product undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.