Description

4-[(4-Chloro-2-Pyrimidinyl)Amino]Benzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrimidine and benzonitrile structure. This compound is critical for the synthesis of targeted small molecule therapeutics, offering a precise chemical scaffold for drug discovery and development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in creating novel active pharmaceutical ingredients (APIs) for oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small molecule drugs, particularly kinase inhibitors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Oncology Drug Candidates: Serves as a core scaffold in the development of targeted cancer therapies.
• Chemical Synthesis: Employed in organic synthesis for constructing complex heterocyclic compounds.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP-scale API production.
• Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	4-[(4-Chloro-2-Pyrimidinyl)Amino]Benzonitrile
CAS No.	244768-32-9
Molecular Formula	C11H7ClN4
Molecular Weight	230.65 g/mol
Synonyms	4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile; 4-(4-Chloro-2-pyrimidinylamino)benzonitrile; 4-(4-Chloro-pyrimidin-2-ylamino)-benzonitrile; Benzonitrile, 4-[(4-chloro-2-pyrimidinyl)amino]-; 244768-32-9; 4-(4-Chloro-2-pyrimidinylamino)benzonitrile; 4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile
EINECS	Contact for details

Quality Control

Our 4-[(4-Chloro-2-Pyrimidinyl)Amino]Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.