Description

3,5-Bis(Trifluoromethyl)-4-Methylaniline is a high-value fluorinated aromatic amine building block, prized for its unique electronic and steric properties imparted by the trifluoromethyl groups. This compound is essential for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced lipophilicity, metabolic stability, and bioavailability are critical. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors, receptor antagonists, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the CF3 groups contribute to improved biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Fluorinated Dye and Pigment Intermediate: Acts as a building block for creating dyes and pigments with unique color fastness and chemical resistance properties.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)-4-Methylaniline
CAS No.	243139-67-5
Molecular Formula	C10H7F6N
Molecular Weight	255.16 g/mol
Synonyms	4-Methyl-3,5-bis(trifluoromethyl)aniline; 4-Methyl-3,5-bis(trifluoromethyl)benzenamine; 3,5-Bis(trifluoromethyl)-p-toluidine; 4-Amino-2,6-bis(trifluoromethyl)toluene; 2,6-Bis(trifluoromethyl)-4-aminotoluene; 4-Methyl-α,α,α,α',α',α'-hexafluoro-m-xylidine; Benzenamine, 4-methyl-3,5-bis(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)-4-Methylaniline is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your cGMP or research-grade needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.