Description

1H-Inden-1-One,2-Fluoro-2,3-Dihydro-2-Methyl-,(2R)-(9Ci) is a high-purity chiral fluorinated indanone derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in asymmetric synthesis. Its value lies in the precise stereochemistry and fluorine atom, which are essential for modulating the biological activity, metabolic stability, and bioavailability of target drug candidates. This compound is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel therapeutic agents and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Asymmetric Synthesis: Utilized as a sophisticated building block for constructing complex, enantiomerically pure molecules through reactions like Michael additions or alkylations.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the impact of fluorination and specific stereochemistry on drug potency and selectivity.
• Agrochemical Synthesis: Acts as a precursor in the development of new generation pesticides and herbicides, where the fluorine moiety enhances stability and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in enantioselective transformations.
• Fine Chemical Production: Used in the custom synthesis of specialty fluorinated compounds for advanced material science and electronics applications.

Basic Information

Product Name	1H-Inden-1-One,2-Fluoro-2,3-Dihydro-2-Methyl-,(2R)-(9Ci)
CAS No.	242484-65-7
Molecular Formula	C10H9FO
Molecular Weight	164.18 g/mol
Synonyms	(2R)-2-Fluoro-2-methyl-2,3-dihydro-1H-inden-1-one; (R)-2-Fluoro-2-methylindan-1-one; 2-Fluoro-2-methyl-2,3-dihydro-1H-inden-1-one, (2R)-; 242484-65-7; (R)-2-Fluoro-2-methyl-2,3-dihydro-1H-inden-1-one; (2R)-2-Fluoro-2-methylindan-1-one; 1H-Inden-1-one, 2-fluoro-2,3-dihydro-2-methyl-, (2R)-; (R)-FMIO
EINECS	Contact for details

Quality Control

Our 1H-Inden-1-One,2-Fluoro-2,3-Dihydro-2-Methyl-,(2R)-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged exposure. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.