Description

Zoniporide Dihydrochloride is a potent and selective sodium-hydrogen exchanger subtype 1 (NHE-1) inhibitor, supplied as a high-purity dihydrochloride salt. This compound is a critical research tool and pharmaceutical intermediate for the development of cardioprotective agents, particularly in the context of ischemia-reperfusion injury. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on cardiovascular drug discovery and development.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel cardioprotective drugs.
• Cardiovascular Disease Studies: Used as a selective NHE-1 inhibitor in preclinical and in vitro studies to investigate mechanisms of myocardial infarction, ischemia-reperfusion injury, and heart failure.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays and enzymatic studies to identify and characterize NHE-1 activity and inhibition.
• Fine Chemical Synthesis: Acts as a crucial building block for the synthesis of more complex molecules and analogs within medicinal chemistry programs.
• Academic Research: Utilized in university and institutional labs for fundamental research into ion transport physiology and cellular injury pathways.

Basic Information

Product Name	Zoniporide Dihydrochloride
CAS No.	241800-97-5
Molecular Formula	C15H19N5O2 • 2HCl
Molecular Weight	398.27 g/mol (free base: 301.35)
Synonyms	Zoniporide HCl; 1-(Quinolin-5-ylsulfonyl)-1H-pyrrole-2-carbonitrile dihydrochloride; 1-[(5-Quinolinyl)sulfonyl]-1H-pyrrole-2-carbonitrile dihydrochloride; NHE-1 Inhibitor; CPR 100893; CPR-100893; CAS 241800-97-5
EINECS	Contact for details

Quality Control

Our Zoniporide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.