Description

Glutamate Caged CAS NO 239135-34-3 is a specialized photolabile protecting group derivative of the essential neurotransmitter L-glutamic acid. This compound is of critical importance for advanced neuroscience and cell biology research, enabling precise, spatiotemporal control over glutamate release in biological systems. It is primarily utilized by research scientists and pharmaceutical developers in neuropharmacology, synaptic physiology, and optogenetics studies.

Application

• Photochemical Uncaging in Neuroscience: Enables millisecond-precision, localized release of glutamate to study receptor kinetics, synaptic transmission, and neural circuitry.
• Cellular Signaling Research: Used to investigate the role of glutamate in intracellular signaling pathways, calcium dynamics, and second messenger systems.
• Drug Discovery & Target Validation: Serves as a critical tool for high-throughput screening of glutamate receptor modulators (e.g., NMDA, AMPA, kainate receptors) and validating novel therapeutic targets.
• Optogenetics & Hybrid Tools: Functions as a complementary chemical tool to optical methods for controlling neuronal activity with high spatial and temporal resolution.
• Neurotoxicity & Disease Modeling: Facilitates studies on excitotoxicity, a process implicated in stroke, traumatic brain injury, and neurodegenerative diseases like Alzheimer's.
• Developmental Biology: Applied to understand the role of glutamatergic signaling in neural development, plasticity, and axon guidance.

Basic Information

Product Name	Glutamate Caged
CAS No.	239135-34-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	α-Carboxy-2-nitrobenzyl glutamate; CNB-glutamate; Caged L-Glutamate; Photolabile L-Glutamate; 4-Carboxymethoxy-5,7-dinitroindolinyl-L-glutamate; (S)-2-Amino-4-([(2-nitrophenyl)methoxy]carbonyl)butanoic acid; Glutamate, α-carboxy-2-nitrobenzyl ester
EINECS	Contact for details

Quality Control

Our Glutamate Caged is produced under strict quality management protocols to ensure the high purity and batch-to-batch consistency required for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Solubility	Soluble in aqueous buffer (pH >6), DMSO
Photolysis Efficiency	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.