Description

Pyr-Trp-Gly-Nh2 CAS NO 239134-47-5 is a synthetic tripeptide derivative, featuring a pyroglutamyl (Pyr) N-terminal modification and a C-terminal amide. This specific molecular architecture is crucial for enhancing metabolic stability and receptor binding affinity in advanced research applications. It is primarily utilized by pharmaceutical R&D and biotechnology companies engaged in peptide-based drug discovery, neurobiological studies, and the development of diagnostic tools.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the discovery and optimization of novel peptide therapeutics.
• Neuroscience Studies: Used as a research tool to investigate neuropeptide pathways, receptor-ligand interactions, and signal transduction mechanisms.
• Bioconjugation & Probe Development: Acts as a building block for creating labeled peptides (e.g., fluorescent, radioactive) for imaging and diagnostic assays.
• Enzyme Substrate & Inhibitor Studies: Employed in biochemical assays to study the activity and specificity of proteases and other modifying enzymes.
• Academic Research: Supports fundamental chemical and biological research in university and institutional laboratories.
• Quality Control & Analytical Standards: Functions as a high-purity certified reference material (CRM) for method validation and quality assurance in analytical laboratories.

Basic Information

Product Name	Pyr-Trp-Gly-Nh2
CAS No.	239134-47-5
Molecular Formula	C19H23N5O4
Molecular Weight	385.42 g/mol
Synonyms	L-Pyroglutamyl-L-tryptophylglycinamide; Pyr-Trp-Gly-NH2; pGlu-Trp-Gly-NH2; Pyroglutamyl-Tryptophyl-Glycine Amide; 5-Oxo-L-prolyl-L-tryptophylglycinamide; H-pGlu-Trp-Gly-NH2; L-Pyroglutamyl-L-tryptophan-glycine amide; TRH-Related Tripeptide
EINECS	Contact for details

Quality Control

Every batch of Pyr-Trp-Gly-Nh2 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality standards are designed to meet the rigorous demands of research and development, ensuring reliable and reproducible results for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.