Description

2-Fluoro-6-(Trifluoromethyl)Benzyl Bromide is a versatile and highly functionalized benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of fluorine and bromine substituents, which enables precise molecular modifications essential for developing high-performance materials and active compounds. This intermediate is particularly vital for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to introduce fluorinated motifs and reactive handles into complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and pesticides where the trifluoromethyl and fluorine groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs) in material science research.
• Fluorinated Liquid Crystal & Polymer Chemistry: Essential monomer for creating fluorinated polymers and liquid crystal displays (LCDs) with improved thermal and chemical resistance.
• Cross-Coupling Reactions: Serves as an efficient electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-Fluoro-6-(Trifluoromethyl)Benzyl Bromide
CAS No.	239087-08-2
Molecular Formula	C8H5BrF4
Molecular Weight	257.03 g/mol
Synonyms	α-Bromo-2-fluoro-6-(trifluoromethyl)toluene; (2-Fluoro-6-(trifluoromethyl)phenyl)methyl bromide; 1-(Bromomethyl)-2-fluoro-3-(trifluoromethyl)benzene; 2-Fluoro-α-(bromomethyl)-α,α,α-trifluorotoluene; 2-Fluoro-6-trifluoromethylbenzyl bromide; Benzene, 1-(bromomethyl)-2-fluoro-3-(trifluoromethyl)-; Bromo(2-fluoro-6-(trifluoromethyl)phenyl)methane
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.