Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]-2-pyrrolidinyl]-1,5-dihydro- is a high-purity nucleoside analog derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and key intermediate for the synthesis of novel antiviral and anticancer agents, particularly those targeting nucleotide metabolism. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of next-generation therapeutics. The product is supplied with a focus on stringent quality control to ensure reliability for sensitive synthetic applications.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of nucleoside-based antiviral drugs.
• Anticancer Drug Research: Used in the R&D of novel chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and kinase pathways.
• Pro-drug Development: Utilized in the design and synthesis of phosphate pro-drugs to enhance bioavailability of active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.

Basic Information

Item	Details
Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]-2-pyrrolidinyl]-1,5-dihydro-
CAS No.	238434-67-8
Molecular Formula	C11H15N3O8P
Molecular Weight	348.23 g/mol
Synonyms	7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(phosphonooxymethyl)pyrrolidin-2-yl]-4H-pyrrolo[3,2-d]pyrimidin-4-one; (2S,3S,4R,5R)-2-(4-Oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(phosphonooxymethyl)pyrrolidine-3,4-diol; 7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-((phosphonooxy)methyl)pyrrolidin-2-yl)-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-one; A Phosphorylated Pyrrolopyrimidine Nucleoside Analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our 4H-Pyrrolo[3,2-d]pyrimidin-4-one derivative is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced techniques like HPLC and NMR. Our quality protocols are designed to meet the exacting standards required for pharmaceutical R&D and GMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.