Description

L-Glutamine, 4-Fluoro-, (4R)- (9Ci) is a specialized, non-proteinogenic amino acid derivative featuring a fluorine atom at the 4-position of the glutamine side chain. This fluorinated analog is a critical building block in medicinal chemistry and pharmaceutical research, offering unique metabolic and biochemical properties for probing biological systems. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, enzyme inhibitors, and metabolic tracers.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon for the synthesis of fluorinated peptide-based drugs and enzyme inhibitors.
• Metabolic Research: Used as a probe to study glutamine metabolism and transport in cells, particularly in cancer and immunology research.
• Proteomics & Biochemistry: Incorporated into peptides and proteins to investigate structure-activity relationships (SAR) and stability.
• PET Tracer Development: Acts as a precursor for developing positron emission tomography (PET) imaging agents targeting glutaminase activity in tumors.
• Chemical Biology Tool: Utilized to create activity-based probes for labeling and identifying specific enzymes in complex biological mixtures.

Basic Information

Product Name	L-Glutamine, 4-Fluoro-, (4R)- (9Ci)
CAS No.	238418-71-8
Molecular Formula	C5H9FN2O3
Molecular Weight	164.14 g/mol
Synonyms	(2S)-2-Amino-4-fluoro-4-oxobutanoic acid; (S)-2-Amino-4-fluorosuccinamic acid; 4-Fluoro-L-glutamine; (4R)-4-Fluoroglutamine; L-4-Fluoroglutamine; F-Gln; 4-F-Gln; (2S)-2-Amino-4-fluoro-4-oxobutanamide
EINECS	Contact for details

Quality Control

Our L-Glutamine, 4-Fluoro-, (4R)- (9Ci) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.