Description

D-Glutamine, 4-Fluoro-, (4S)-Rel- (9Ci) CAS NO 238418-67-2 is a high-purity, non-natural amino acid derivative characterized by a fluorine atom at the 4-position of the glutamine side chain and a specific (S) configuration. This compound is a critical chiral building block and research chemical for advanced pharmaceutical development and biochemical studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel peptides, enzyme inhibitors, and metabolic probes. The precise stereochemistry and fluorination make it a valuable tool for modulating biological activity and studying protein interactions.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disorder research.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate glutamine metabolism and fluorine's role in bioisosteric replacement.
• Peptide Synthesis: Incorporated into custom peptides to enhance stability, modulate receptor binding affinity, or introduce spectroscopic probes for structural analysis.
• Proteomics & Metabolomics: Serves as a standard or labeled analog in mass spectrometry-based studies for quantifying metabolic pathways.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorinated amino acids on drug potency and pharmacokinetics.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis, chemical biology, and fluorine chemistry.

Basic Information

Product Name	D-Glutamine, 4-Fluoro-, (4S)-Rel- (9Ci)
CAS No.	238418-67-2
Molecular Formula	C5H9FN2O3
Molecular Weight	164.14 g/mol
Synonyms	(2S)-2-Amino-4-fluoro-4-oxobutanoic acid; (S)-2-Amino-4-fluorosuccinamic acid; 4-Fluoro-D-glutamine; D-4-Fluoroglutamine; (4S)-4-Fluoroglutamine; Rel-(4S)-4-Fluoroglutamine; 238418-67-2; 9CI
EINECS	Contact for details

Quality Control

Our D-Glutamine, 4-Fluoro-, (4S)-Rel- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.