Description

Tirofiban CAS NO 237763-52-9 is a potent, non-peptide glycoprotein IIb/IIIa receptor antagonist, functioning as a highly selective antiplatelet agent. Its primary value lies in its critical role in the prevention of thrombotic complications during and after percutaneous coronary interventions (PCI). This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing injectable anticoagulant and antiplatelet therapies, particularly for patients with acute coronary syndromes.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of injectable antiplatelet drugs.
• Key component in medications for the management of acute coronary syndromes (ACS), including unstable angina and non-Q-wave myocardial infarction.
• Used in therapeutic regimens to prevent cardiac ischemic complications during and after percutaneous coronary interventions (PCI) such as angioplasty.
• Critical for the development of generic pharmaceutical products following patent expirations.
• Utilized in clinical research for studying platelet aggregation and thrombosis mechanisms.
• Employed in the synthesis of reference standards for analytical and quality control purposes.

Basic Information

Product Name	Tirofiban
CAS No.	237763-52-9
Molecular Formula	C22H36N2O5S
Molecular Weight	440.60 g/mol
Synonyms	Tirofiban Hydrochloride; L-700,462; MK-383; Aggrastat; N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine; (2S)-2-[[(Butylsulfonyl)amino]methyl]-3-(4-hydroxyphenyl)propanoic acid; 1-Piperidinebutanoic acid derivative
EINECS	Contact for details

Quality Control

Our Tirofiban is manufactured under strict quality management systems, ensuring it meets the stringent requirements for pharmaceutical actives. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral purity determination, and residual solvent analysis, in compliance with ICH guidelines. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Specific Rotation	-10.0° to -14.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.