Description

Amyloid β-Protein (10-35) is a synthetic peptide fragment corresponding to residues 10-35 of the human amyloid beta (Aβ) protein, a key component in the study of neurodegenerative diseases. This high-purity research chemical is critical for investigating the aggregation mechanisms, neurotoxicity, and structural biology underlying conditions like Alzheimer's disease. It is an essential tool for academic researchers, pharmaceutical R&D teams, and diagnostic developers focused on neuroscience, drug discovery, and biomarker analysis.

Application

• Neuroscience Research: Fundamental studies on amyloid beta aggregation kinetics, fibril formation, and oligomer toxicity.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and evaluate potential therapeutic inhibitors of Aβ aggregation.
• Biophysical Characterization: Employed in techniques like NMR, CD spectroscopy, and X-ray crystallography to determine peptide structure and folding.
• Antibody Development & Validation: Serves as an antigen for the production and testing of antibodies used in diagnostic immunoassays and imaging.
• Cell-based Assays: Used to induce and model cellular stress and toxicity in neuronal cell cultures.
• Biomarker Research: A reference standard in the development of analytical methods (e.g., HPLC, MS) for detecting Aβ peptides in biological samples.

Basic Information

Product Name	Amyloid β-Protein (10-35)
CAS No.	237753-66-1
Molecular Formula	C130H203N41O43
Molecular Weight	2944.2 g/mol
Synonyms	Aβ(10-35); Amyloid β-Protein (10-35); Amyloid β-Peptide (10-35); β-Amyloid Protein Fragment 10-35; Aβ10-35; Amyloid Beta (10-35); Alzheimer's Disease Amyloid Peptide (10-35); H-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (10-35) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and Mass Spectrometry for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and analytical data to support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥95%
Peptide Content	≥70% (by weight)
Solubility	Soluble in water or dilute acetic acid
Water Content (KF)	≤5.0%
Single Impurity (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.