Description

2,3,4,5-Tetrafluorobenzylamine is a versatile fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the tetrafluoro substitution pattern, which is critical for modulating the biological activity and physicochemical characteristics of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-based drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance lipophilicity, metabolic stability, and binding affinity.
• Ligand & Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, leveraging the benzylamine functionality for complexation.
• Functional Material Production: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and electronic materials requiring thermal stability and specific dielectric properties.
• Peptide Mimetics & Bioconjugation: The primary amine group is utilized for coupling reactions to create peptide analogs or for bioconjugation linkers in diagnostic and therapeutic agents.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination strategies and structure-activity relationships (SAR).

Basic Information

Product Name	2,3,4,5-Tetrafluorobenzylamine
CAS No.	235088-70-7
Molecular Formula	C7H5F4N
Molecular Weight	179.12 g/mol
Synonyms	(2,3,4,5-Tetrafluorophenyl)methanamine; 2,3,4,5-Tetrafluorobenzyl Amine; 2,3,4,5-Tetrafluorobenzenemethanamine; α-Amino-2,3,4,5-tetrafluorotoluene; 4-Amino-1,2,3,5-tetrafluorobenzene; Tetrafluorobenzylamine; TFBA; 235088-70-7
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrafluorobenzylamine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.