Description

3,4,5-Trifluorobenzylamine is a versatile fluorinated aromatic amine building block of significant importance in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the trifluoromethyl-substituted benzyl group, which is crucial for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, CNS agents, and anti-infective drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and advanced electronic materials.
• Peptide Modification: Used to introduce fluorinated benzyl groups into peptides to study structure-activity relationships and improve bioavailability.
• Chemical Biology Probes: Acts as a building block for fluorescent tags and molecular probes used in biochemical assays and diagnostic research.

Basic Information

Product Name	3,4,5-Trifluorobenzylamine
CAS No.	235088-69-4
Molecular Formula	C7H6F3N
Molecular Weight	161.12 g/mol
Synonyms	(3,4,5-Trifluorophenyl)methanamine; 3,4,5-Trifluorobenzenemethanamine; 3,4,5-Trifluorobenzyl amine; α-Amino-3,4,5-trifluorotoluene; Benzenemethanamine, 3,4,5-trifluoro-; 3,4,5-Trifluoro-Benzylamine
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorobenzylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and acids. Due to its basic nature and sensitivity to moisture, containers should be kept tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.