Description

L-Isoleucine, 3-Hydroxy-4-Methyl- (9Ci) is a specialized, non-proteinogenic amino acid derivative with a unique hydroxylated side chain. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its role as a key chiral building block or metabolic intermediate. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications such as peptide synthesis, metabolic pathway studies, and the development of novel therapeutic agents. Its precise stereochemistry and functional groups make it a valuable tool for probing biological mechanisms and creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of complex drug candidates, especially those targeting metabolic disorders or requiring specific stereochemical configurations.
• Biochemical Research: Used as a standard or probe in enzymatic studies, metabolic pathway analysis (e.g., branched-chain amino acid metabolism), and isotope labeling experiments.
• Peptide Modification: Incorporated into synthetic peptides to introduce hydroxyl functionality, altering solubility, bioavailability, or receptor binding properties for research purposes.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, or NMR for method development, validation, and quality control in analytical laboratories.
• Nutraceutical R&D: Investigated for potential applications in specialized nutritional supplements or clinical nutrition products due to its structural relation to essential amino acids.

Basic Information

Product Name	L-Isoleucine, 3-Hydroxy-4-Methyl- (9Ci)
CAS No.	231609-91-9
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	(2S,3S)-3-Hydroxy-4-methyl-2-aminopentanoic acid; L-3-Hydroxy-4-methylisoleucine; (2S,3S)-3-Hydroxy-4-methylisoleucine; 3-Hydroxy-L-4-methylisoleucine; HmIle; 3-Hydroxy-4-methyl-L-isoleucine; 4-Methyl-3-hydroxy-L-isoleucine; (2S,3S)-4-Methyl-3-hydroxyleucine
EINECS	Contact for details

Quality Control

Our L-Isoleucine, 3-Hydroxy-4-Methyl- (9Ci) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including chiral purity verification and impurity profiling. A detailed Certificate of Analysis (COA) is provided, documenting identity, purity (typically ≥95% by HPLC), and specific analytical data. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% (L-isomer)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.