Description

6,7-Dimethoxy-n-(2-Nitrophenyl)Quinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent and selective kinase inhibitors for cancer therapy.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Biochemical Tool Compound: Serves as a reference standard or a core scaffold for probing biological pathways and target validation in vitro.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	6,7-Dimethoxy-n-(2-Nitrophenyl)Quinazolin-4-Amine
CAS No.	229476-52-2
Molecular Formula	C₁₆H₁₄N₄O₄
Molecular Weight	326.31 g/mol
Synonyms	4-Amino-6,7-dimethoxy-N-(2-nitrophenyl)quinazoline; N-(2-Nitrophenyl)-6,7-dimethoxyquinazolin-4-amine; 6,7-Dimethoxy-N-(2-nitrophenyl)-4-quinazolinamine; 229476-52-2; Quinazolin-4-amine, 6,7-dimethoxy-N-(2-nitrophenyl)-; 4-Quinazolinamine, 6,7-dimethoxy-N-(2-nitrophenyl)-
EINECS	Contact for details

Quality Control

Our 6,7-Dimethoxy-n-(2-Nitrophenyl)Quinazolin-4-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.