Description

H-D-Glu(Trp-Oh)-Oh CAS NO 229305-39-9 is a protected dipeptide derivative, specifically the H-D-Glutamic acid α-1-(tryptophan) derivative, serving as a crucial chiral building block in advanced organic synthesis. This compound is valued for its role in constructing complex peptide architectures and bioactive molecules with high stereochemical fidelity. It is primarily utilized by research institutions and pharmaceutical development teams working on novel therapeutic peptides, peptidomimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce specific glutamic acid and tryptophan motifs into peptide chains.
• Bioconjugation & Probe Development: Serves as a starting material for creating fluorescent probes, affinity labels, or other bioconjugates due to the reactive functional groups and the indole moiety of tryptophan.
• Chemical Biology Research: Employed in studying enzyme-substrate interactions, receptor binding, and the structure-activity relationships (SAR) of peptides.
• Fine Chemical Production: Acts as a building block for the synthesis of complex, high-value non-peptide molecules in fine chemical and custom manufacturing.

Basic Information

Item	Details
Product Name	H-D-Glu(Trp-Oh)-Oh
CAS No.	229305-39-9
Molecular Formula	C₁₉H₂₃N₃O₆
Molecular Weight	389.41 g/mol
Synonyms	H-D-Glu(Trp-OH)-OH; H-D-Glutamic acid α-1-(tryptophan); (2S)-2-[[(2S)-2-Amino-4-carboxy-1-oxobutyl]amino]-3-(1H-indol-3-yl)propanoic acid; D-Glu(Trp-OH)-OH; Fmoc-D-Glu(Trp(Boc)-OH)-OH (precursor); Protected D-Glutamyl-Tryptophan derivative; Chiral dipeptide building block; 229305-39-9
EINECS	Contact for details

Quality Control

Every batch of H-D-Glu(Trp-Oh)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards typical for advanced pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.