Description

(S)-tert-Butyl 2-(2-Hydroxyethyl)Azetidine-1-Carboxylate is a high-purity chiral azetidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined azetidine scaffold with a functionalized side chain, enabling efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of new drug candidates, especially in protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Building block for creating novel, stereoselective pesticides and herbicides with enhanced efficacy.
• Ligand and Catalyst Development: Precursor for synthesizing chiral ligands used in asymmetric catalysis.
• Peptidomimetics Research: Used to incorporate constrained azetidine rings into peptide backbones to improve metabolic stability and bioavailability.
• Chemical Biology Probes: Foundation for creating tool compounds to study biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for clinical trials and commercial APIs.

Basic Information

Product Name	(S)-tert-Butyl 2-(2-Hydroxyethyl)Azetidine-1-Carboxylate
CAS No.	228868-29-9
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	1-Boc-(2S)-2-(2-Hydroxyethyl)azetidine; (S)-1-(tert-Butoxycarbonyl)-2-(2-hydroxyethyl)azetidine; tert-Butyl (2S)-2-(2-hydroxyethyl)azetidine-1-carboxylate; (S)-1-Boc-2-(2-hydroxyethyl)azetidine; Azetidine-1-carboxylic acid, 2-(2-hydroxyethyl)-, 1,1-dimethylethyl ester, (2S)-; BOC-Azetidine-(S)-ethanol
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-(2-Hydroxyethyl)Azetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.