Description

Ethyl 2-Chloro-4-(m-Tolylamino)Pyrimidine-5-Carboxylate is a high-value pyrimidine derivative and a key synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both chloro and tolylamino substituents, makes it a versatile building block for constructing complex heterocyclic systems. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates, particularly those targeting kinase inhibition and other therapeutic pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators where the pyrimidine core is a common bioactive motif.
• Material Science: Acts as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in heterocyclic chemistry and medicinal chemistry programs.
• Fine Chemical Synthesis: A building block for creating complex dyes, pigments, and other high-value specialty chemicals.

Basic Information

Product Name	Ethyl 2-Chloro-4-(m-Tolylamino)Pyrimidine-5-Carboxylate
CAS No.	227449-09-4
Molecular Formula	C14H14ClN3O2
Molecular Weight	291.73 g/mol
Synonyms	2-Chloro-4-[(3-methylphenyl)amino]-5-pyrimidinecarboxylic acid ethyl ester; Ethyl 2-chloro-4-[(3-methylphenyl)amino]-5-pyrimidinecarboxylate; 4-(m-Tolylamino)-2-chloropyrimidine-5-carboxylic acid ethyl ester; 227449-09-4; 2-Chloro-4-(3-methylanilino)pyrimidine-5-carboxylic acid ethyl ester; Ethyl 2-chloro-4-(3-methylphenylamino)pyrimidine-5-carboxylate; m-Tolylamino pyrimidine carboxylate derivative
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-Chloro-4-(m-Tolylamino)Pyrimidine-5-Carboxylate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.