Description

m-(Trimethylsilyldifluoromethyl)Aniline is a specialized organosilicon and fluorine-containing aromatic amine building block, identified by CAS NO 223683-81-6. This compound is valued for its unique combination of a reactive aniline group with a highly lipophilic and electron-withdrawing trimethylsilyldifluoromethyl moiety, enabling precise molecular design. It is primarily sought by researchers and process chemists in the pharmaceutical and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the difluoromethyl group into drug candidates, potentially enhancing metabolic stability and membrane permeability.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides where the silicon-fluorine unit can influence biological activity and environmental fate.
• Material Science: Serves as a monomer or cross-linking agent for synthesizing specialty silicones, fluoropolymers, and high-performance resins with tailored surface properties.
• Liquid Crystal & OLED Development: Incorporated into organic semiconductors and liquid crystal molecules to modify electronic properties and intermolecular interactions.
• Catalyst Ligand Synthesis: Used to create novel ligand frameworks for transition metal catalysis in asymmetric synthesis.
• Proteolysis-Targeting Chimeras (PROTACs): A potential building block for linker or warhead components in targeted protein degradation therapeutics.

Basic Information

Product Name	m-(Trimethylsilyldifluoromethyl)Aniline
CAS No.	223683-81-6
Molecular Formula	C10H15F2NSi
Molecular Weight	215.32 g/mol
Synonyms	3-[(Trimethylsilyl)difluoromethyl]aniline; Benzenamine, 3-[(trimethylsilyl)difluoromethyl]-; m-(Trimethylsilyldifluoromethyl)phenylamine; 3-(Trimethylsilyldifluoromethyl)aniline; Aniline, m-(trimethylsilyldifluoromethyl)-; (3-Aminophenyl)(difluoro)trimethylsilane
EINECS	Contact for details

Quality Control

Our production of m-(Trimethylsilyldifluoromethyl)Aniline adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for research and development. Each lot is characterized by modern analytical techniques including NMR, GC-MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.