Description

Fmoc-5-Cyano-L-Tryptophan is a protected, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for introducing a unique, functionalized tryptophan side chain into peptide sequences, enabling the study of protein structure and function or the development of novel bioactive molecules. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic laboratories focused on peptide-based drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of complex peptides containing modified tryptophan residues.
• Peptide Drug Discovery: Used to incorporate a cyano-functionalized indole moiety into peptide leads, potentially enhancing binding affinity, metabolic stability, or introducing a spectroscopic probe.
• Chemical Biology Probes: Serves as a precursor for synthesizing fluorescent or photoaffinity labels to study protein-protein interactions and enzyme mechanisms.
• Peptidomimetic Development: Enables the creation of novel peptide analogs with tailored physicochemical properties for therapeutic applications.
• Academic Research: Fundamental tool for studying the role of specific amino acid modifications in peptide folding, stability, and biological activity.

Basic Information

Product Name	Fmoc-5-Cyano-L-Tryptophan
CAS No.	223581-98-4
Molecular Formula	C₂₉H₂₃N₃O₄
Molecular Weight	477.51 g/mol
Synonyms	Fmoc-5-Cyano-L-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-cyano-L-tryptophan; 5-Cyano-L-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-Trp(5-CN)-OH; Fmoc-5-CN-L-Trp; N-Fmoc-5-cyano-L-tryptophan; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(5-cyano-1H-indol-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-5-Cyano-L-Tryptophan is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer requirements for advanced peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.