Description

L-Proline, 2-Methyl-4-Methylene- (9Ci) is a specialized, non-proteinogenic proline derivative characterized by its unique methyl and methylene substituents. This compound is of significant interest in advanced organic synthesis and pharmaceutical research, serving as a sophisticated chiral building block for the development of novel bioactive molecules. It is primarily utilized by research institutions and chemical manufacturers focused on peptide mimetics, medicinal chemistry, and the synthesis of complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor design.
• Peptidomimetics Research: Used to introduce conformational constraints and novel side-chain functionalities into synthetic peptides to enhance stability and biological activity.
• Asymmetric Synthesis: Employed as a building block in stereoselective synthesis for constructing complex molecular architectures.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to probe active site mechanisms.
• Agrochemical Development: Potential application in the synthesis of novel, biologically active compounds for crop protection.
• Material Science: Exploration as a monomer or functional component in specialty polymers and smart materials.

Basic Information

Product Name	L-Proline, 2-Methyl-4-Methylene- (9Ci)
CAS No.	223244-44-8
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(2S)-2-Methyl-4-methylenepyrrolidine-2-carboxylic acid; 2-Methyl-4-methyleneproline; 4-Methylene-2-methyl-L-proline; L-2-Methyl-4-methyleneproline; (S)-2-Methyl-4-methylenepyrrolidine-2-carboxylic acid; 2-Methyl-4-methylenepyrrolidine-2-carboxylic acid, (S)-; 4-Methylene-2-methylproline
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemicals. Production of L-Proline, 2-Methyl-4-Methylene- (9Ci) adheres to current Good Manufacturing Practices (cGMP) where applicable. Each batch is analyzed using advanced techniques including HPLC, NMR, and chiral analysis to ensure identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.