Description

4H-Pyrrolo3,2-Dpyrimidin-4-One, 7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-1,5-Dihydro-2-Methyl- is a high-purity, complex heterocyclic compound with significant potential in advanced pharmaceutical research and development. This molecule serves as a critical chiral building block for the synthesis of novel therapeutic agents, particularly in the fields of oncology and antiviral drug discovery. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Oncology Research: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapies.
• Antiviral Drug Development: Used in research programs aimed at creating novel nucleoside/nucleotide analogs for treating viral infections.
• Chemical Biology & Proteomics: Employed as a tool compound or a precursor for affinity probes to study enzyme function and protein-ligand interactions.
• Process Chemistry & Scale-Up: Supplied to support route scouting, optimization, and pilot-scale manufacturing of advanced intermediates.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and medicinal chemistry.

Basic Information

Item	Details
Product Name	4H-Pyrrolo3,2-Dpyrimidin-4-One, 7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-1,5-Dihydro-2-Methyl-
CAS No.	222854-93-5
Molecular Formula	C12H16N4O3
Molecular Weight	264.28 g/mol
Synonyms	7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-methylpyrrolidin-2-yl]-2-methyl-4H,5H-pyrrolo[3,2-d]pyrimidin-4-one; (2S,3S,4R,5R)-2-(2-Methyl-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-methylpyrrolidine-3,4-diol; 7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-methyl-2-pyrrolidinyl-1,5-dihydro-2-methyl-4H-pyrrolo[3,2-d]pyrimidin-4-one; A Chiral Pyrrolopyrimidinone Derivative; Advanced Pharmaceutical Intermediate 222854-93-5.
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Standard quality control includes comprehensive analytical testing via HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters. Our production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring suitability for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment after opening to prevent degradation. Long-term storage at 2-8°C is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.