Description

4H-Pyrrolo3,2-Dpyrimidin-4-One, 2-Amino-7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-1,5-Dihydro-, Monohydrochloride is a high-purity, complex heterocyclic compound with significant pharmaceutical relevance. This monohydrochloride salt form offers enhanced stability and solubility for research and development applications. It is primarily utilized as a critical pharmaceutical intermediate or reference standard in the synthesis of novel therapeutic agents, particularly within oncology and antiviral drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel nucleoside analog drugs.
• Oncology Research: Used in the development of targeted cancer therapies and kinase inhibitors.
• Antiviral Drug Development: Serves as a precursor for compounds being investigated for antiviral activity.
• Biochemical Research: Employed as a tool compound in enzymatic studies and biological pathway analysis.
• Reference Standard: Provides a high-purity benchmark for quality control, analytical method development, and regulatory submissions.
• Process Chemistry: Used in scale-up and optimization studies for active pharmaceutical ingredient (API) manufacturing.

Basic Information

Item	Details
Product Name	4H-Pyrrolo3,2-Dpyrimidin-4-One, 2-Amino-7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-1,5-Dihydro-, Monohydrochloride
CAS No.	222854-90-2
Molecular Formula	C12H17N5O3 • HCl
Molecular Weight	307.75 g/mol (Free base: 271.29 g/mol)
Synonyms	2-Amino-7-((2S,3S,4R,5R)-3,4-dihydroxy-5-methylpyrrolidin-2-yl)-4H,5H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; 2-Amino-7-((2S,3S,4R,5R)-3,4-dihydroxy-5-methylpyrrolidin-2-yl)-4,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; 2-Amino-7-(3,4-dihydroxy-5-methyl-2-pyrrolidinyl)-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one monohydrochloride; (2S,3S,4R,5R)-2-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-methylpyrrolidine-3,4-diol hydrochloride
EINECS	Contact for details

Quality Control

Our 4H-Pyrrolo3,2-Dpyrimidin-4-One, 2-Amino-7-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-1,5-Dihydro-, Monohydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Chiral Purity (HPLC)	≥ 99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.