Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-, monohydrochloride is a high-purity, complex heterocyclic compound with significant pharmaceutical relevance. This monohydrochloride salt form offers enhanced stability and solubility for research and development applications. It is primarily utilized as a key intermediate or active pharmaceutical ingredient (API) building block in the synthesis of novel therapeutics. This product is essential for pharmaceutical companies and research institutions focused on oncology, antiviral, and other targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleoside analog drugs and other small molecule therapeutics.
• Oncology Research: Used in the development of targeted cancer therapies, particularly those involving kinase inhibition or DNA/RNA synthesis interference.
• Antiviral Drug Development: Serves as a precursor in the research and production of antiviral agents.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies and biochemical assays.
• Preclinical & Clinical Trial Material: Supplied as a high-quality raw material for non-clinical studies and the manufacture of clinical trial batches.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale synthesis for new chemical entities (NCEs).

Basic Information

Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-, monohydrochloride
CAS No.	222854-80-0
Molecular Formula	C12H16ClN5O5
Molecular Weight	345.74 g/mol
Synonyms	2-Amino-7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; 2-Amino-7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; 7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-2-amino-4H-pyrrolo[3,2-d]pyrimidin-4-one monohydrochloride; (2S,3S,4R,5R)-2-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol hydrochloride; A nucleoside analog intermediate; API Intermediate 222854-80-0.
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality management systems, ensuring batch-to-batch consistency and reliability. The material is manufactured and controlled according to current industry best practices, with specifications designed to meet the demanding requirements of pharmaceutical R&D and cGMP environments. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.