Description

Fmoc-L-4-(Otbutylcarboxymethyl)Phe-Oh is a protected, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound matters because it provides a crucial orthogonally protected side chain, allowing for the controlled introduction of carboxylic acid functionality into complex peptide sequences. Pharmaceutical researchers and fine chemical manufacturers need this high-purity building block for the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides.
• Pharmaceutical Intermediates: Used in the research and production of peptide-based drugs, including hormone analogs and targeted therapeutics.
• Bioconjugation: Facilitates the site-specific attachment of peptides to other molecules, such as polymers, dyes, or drug carriers, via its protected carboxylic acid group.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions and cellular processes.
• Material Science: Serves as a monomer for creating peptide-based biomaterials and hydrogels with tailored properties.
• Academic & Industrial R&D: Essential for exploratory research in medicinal chemistry and novel peptide discovery.

Basic Information

Product Name	Fmoc-L-4-(Otbutylcarboxymethyl)Phe-Oh
CAS No.	222842-99-1
Molecular Formula	C₃₁H₃₃NO₇
Molecular Weight	531.60 g/mol
Synonyms	Fmoc-L-4-(2-tert-Butoxy-2-oxoethyl)phenylalanine; Fmoc-4-(O-t-Butylcarboxymethyl)-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-tert-butoxy-2-oxoethyl)oxy]-L-phenylalanine; Fmoc-Phe(4-CH2COOtBu)-OH; Fmoc-L-4-(2-tert-Butoxy-2-oxoethoxy)phenylalanine; Fmoc-Tyr(COOtBu)-OH analog; Nα-Fmoc-O-tert-butyl-L-tyrosylacetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-4-(Otbutylcarboxymethyl)Phe-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.