Description

7H-Pyrazolo4,3-Dpyrimidin-7-One, 5-Amino-3-(2S,3S,4R,5S)-3,4-Dihydroxy-5-(Mercaptomethyl)-2-Pyrrolidinyl-1,4-Dihydro- is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the field of antiviral and oncology drug discovery. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of complex nucleoside analogs and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and anticancer drug candidates.
• Nucleoside Analog Research: Used in the development of modified nucleosides for targeted therapies.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and mechanism of action research.
• Pre-clinical Development: Essential material for producing batches of active pharmaceutical ingredients (APIs) for pre-clinical testing and formulation studies.
• Process Chemistry: Used for route scouting, optimization, and scale-up studies in process development laboratories.
• Reference Standard: High-purity material suitable for use as an analytical reference standard in quality control laboratories.

Basic Information

Product Name	7H-Pyrazolo4,3-Dpyrimidin-7-One, 5-Amino-3-(2S,3S,4R,5S)-3,4-Dihydroxy-5-(Mercaptomethyl)-2-Pyrrolidinyl-1,4-Dihydro-
CAS No.	222631-89-2
Molecular Formula	C11H15N5O3S
Molecular Weight	297.33 g/mol
Synonyms	5-Amino-3-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)pyrrolidin-2-yl]-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-Amino-3-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; Mercaptopurine Nucleoside Analog Intermediate; (2S,3S,4R,5S)-2-(5-Amino-7-oxo-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-(mercaptomethyl)pyrrolidine-3,4-diol
EINECS	Contact for details

Quality Control

Our 7H-Pyrazolo4,3-Dpyrimidin-7-One derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific monograph requirements or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.