Description

7H-Pyrazolo4,3-Dpyrimidin-7-One, 5-Amino-1,4-Dihydro-3-(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl- is a high-purity, complex heterocyclic compound with a defined stereochemistry. This advanced pharmaceutical intermediate is critical for the synthesis of nucleoside analogs and other bioactive molecules targeting specific enzymatic pathways. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing antiviral and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analog drugs.
• Antiviral Drug Research: Used in the development of compounds targeting viral polymerases and reverse transcriptases.
• Oncology Therapeutics: Serves as a precursor for potential anticancer agents that interfere with DNA synthesis and repair.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies and proteomics research.
• Precision Chemical Synthesis: Employed in asymmetric synthesis and chiral chemistry due to its defined stereocenters.
• Contract Manufacturing (CMO/CDMO): Supplied to organizations specializing in the production of high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	7H-Pyrazolo4,3-Dpyrimidin-7-One, 5-Amino-1,4-Dihydro-3-(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl-
CAS No.	222631-87-0
Molecular Formula	C11H14N6O3
Molecular Weight	278.27 g/mol
Synonyms	5-Amino-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrazolo[4,3-d]pyrimidin-7-one; (2R,3S,5R)-2-(5-Amino-7-oxo-7H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3-ol; 5-Amino-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrazolo[4,3-d]pyrimidin-7-one; Acyclic Nucleoside Analog Intermediate; Pyrazolopyrimidinone Nucleoside
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through comprehensive analytical methods including HPLC, chiral analysis, and NMR to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.