Description

1H-Pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-dione, 3-((2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl)- is a sophisticated chiral nucleoside analog derivative, serving as a critical building block in advanced pharmaceutical research and development. Its value lies in its unique molecular architecture, which incorporates a mercaptomethyl-substituted pyrrolidine ring fused to a pyrazolopyrimidinedione core, making it a key precursor for novel therapeutic agents. This compound is essential for medicinal chemists and R&D teams in the pharmaceutical and biotechnology sectors focused on developing antiviral and anticancer drugs, as well as other targeted therapies.

Application

• Pharmaceutical Intermediate: A high-value synthetic precursor for the development of novel nucleoside analog drugs targeting viral infections and cancer.
• Antiviral Drug Research: Used in the synthesis of potential therapeutic agents against a range of viruses due to its modified nucleobase structure.
• Oncology Research: Serves as a building block for creating purine nucleoside phosphorylase (PNP) inhibitors and other anticancer compounds.
• Biochemical Tool Compound: Employed in enzymatic studies and as a probe to investigate nucleoside metabolism and related biological pathways.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) specializing in complex, chiral molecules.

Basic Information

Product Name	1H-Pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-dione, 3-((2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl)-
CAS No.	222631-85-8
Molecular Formula	C11H14N4O5S
Molecular Weight	314.32 g/mol
Synonyms	3-((2S,3S,4R,5S)-3,4-Dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl)-1H-pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-dione; (2S,3S,4R,5S)-2-(5,7-Dioxo-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-(mercaptomethyl)-3,4-dihydroxypyrrolidine; Forodesine Impurity; Forodesine Related Compound; BCX-1777 Intermediate; PNP Inhibitor Intermediate; Immucillin-H Analog; Purine Nucleoside Phosphorylase Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development purposes. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development projects with specifications that can be aligned with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be kept tightly sealed in a cool, dry place and opened only under controlled conditions to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.