Description

1H-Pyrazolo4,3-Dpyrimidine-5,7(4H,6H)-Dione, 3-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl- is a high-purity, complex heterocyclic compound with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate or building block in organic synthesis. Its precise molecular architecture makes it invaluable for the research and development of novel therapeutic agents, particularly in areas requiring specific chiral centers. This product is essential for pharmaceutical R&D laboratories and fine chemical manufacturers focused on creating next-generation drugs, including potential kinase inhibitors or nucleoside analogs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs, especially in oncology and antiviral research.
• Biochemical Probe Development: Serves as a precursor for creating specialized probes and tool compounds to study enzyme mechanisms and biological pathways.
• Nucleoside/Nucleotide Analog Synthesis: The pyrazolopyrimidine-dione core is structurally analogous to purine bases, making it suitable for synthesizing novel nucleoside analogs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce complex, functionalized heterocyclic motifs into target molecules.
• Contract Research & Manufacturing (CRAM): Supplied to organizations engaged in custom synthesis and development of proprietary compounds for clients.

Basic Information

Product Name	1H-Pyrazolo4,3-Dpyrimidine-5,7(4H,6H)-Dione, 3-(2S,3S,4R,5R)-3,4-Dihydroxy-5-Methyl-2-Pyrrolidinyl-
CAS No.	222631-84-7
Molecular Formula	C11H14N4O5
Molecular Weight	282.26 g/mol
Synonyms	3-((2S,3S,4R,5R)-3,4-Dihydroxy-5-methylpyrrolidin-2-yl)-1H-pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-dione; (2S,3S,4R,5R)-2-(5,7-Dioxo-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-methylpyrrolidine-3,4-diol; Pyrazolopyrimidinedione pyrrolidinol derivative; CAS 222631-84-7.
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo4,3-Dpyrimidine-5,7(4H,6H)-Dione derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing key parameters such as assay (HPLC), chiral purity, and impurity profiles. We support cGMP compliance for pharmaceutical applications, and specifications can be aligned with client-specific pharmacopeial or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.