Description

1H-Pyrazolo4,3-Dpyrimidine-5,7(4H,6H)-Dione, 3-(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl- is a high-purity, structurally complex heterocyclic compound that serves as a critical advanced intermediate in modern pharmaceutical synthesis. Its precise stereochemistry and functional groups make it an invaluable building block for the development of novel therapeutic agents. This compound is primarily sought by research institutions and pharmaceutical manufacturers engaged in the discovery and production of nucleoside analog drugs and other targeted small-molecule therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Biochemical Tool Compound: Employed in enzymatic studies and as a probe to investigate purine metabolism pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the development of purine-based therapeutic candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic chemistry and bioorganic mechanisms.

Basic Information

Product Name	1H-Pyrazolo4,3-Dpyrimidine-5,7(4H,6H)-Dione, 3-(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl-
CAS No.	222631-83-6
Molecular Formula	C11H14N4O5
Molecular Weight	282.26 g/mol
Synonyms	3-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-dione; (2R,3R,4S,5R)-2-(5,7-Dioxo-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; AICAR Ribonucleotide Intermediate; AICAR Precursor; 5-Aminoimidazole-4-carboxamide ribonucleotide analog intermediate; ZMP Intermediate; Acadesine Synthetic Intermediate
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo4,3-Dpyrimidine-5,7(4H,6H)-Dione, 3-(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP intermediate use. A detailed Certificate of Analysis (COA) documenting identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.