Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,5-dihydro- is a sophisticated nucleoside analog derivative with significant potential in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate or potential active pharmaceutical ingredient (API) for novel antiviral and anticancer therapeutics, offering a high degree of stereochemical control. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and contract research organizations (CROs) focused on nucleoside-based drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleoside analog drugs.
• Antiviral Drug Research: Investigated for the development of new therapeutics targeting viral polymerases and replication mechanisms.
• Oncology Research: Explored as a potential chemotherapeutic agent or a precursor in anticancer prodrug development.
• Biochemical Tool Compound: Used in enzymatic studies and as a substrate or inhibitor for specific nucleoside-processing enzymes.
• Preclinical Development: Supports lead optimization and preclinical studies for new molecular entities (NMEs).
• Process Chemistry: Utilized in route scouting and scale-up studies for complex API manufacturing.

Basic Information

Item	Details
Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,5-dihydro-
CAS No.	222631-77-8
Molecular Formula	C12H15N5O3S
Molecular Weight	309.35 g/mol
Synonyms	2-Amino-7-((2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)pyrrolidin-2-yl)-4H-pyrrolo[3,2-d]pyrimidin-4-one; 2-Amino-7-((2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl)-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; 2-Amino-7-(3,4-dihydroxy-5-mercaptomethyl-2-pyrrolidinyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one (stereoisomer); Mercaptopurine nucleoside analog; 222631-77-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and development purposes, with quality parameters typically monitored by HPLC for purity and chiral analysis to confirm stereochemical integrity. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient light should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Chiral Purity (Chiral HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.